Frame Reference Time (0054,1300) is the time that the pixel values in the Image occurred. Frame Reference Time is defined as the time offset, in msec, from the Series Reference Time, where the Series Reference Time is defined by the combination of Series Date (0008,0021) and Series Time (0008,0031).

Note: Frame Reference Time (0054,1300) is implementation dependent and may or may not be tied to any real-world event. To illustrate the meaning of Frame Reference Time (0054,1300), the following are some examples of possible implementations:

Example 1: For a long-lived radionuclide and a non-time-varying radiopharmaceutical distribution, an implementation sets the Frame Reference Time (0054,1300) to the midpoint of the Actual Frame Duration (0018,1242).

Example 2: For a short-lived radionuclide and a non-time-varying radiopharmaceutical distribution, an implementation sets the Frame Reference Time (0054,1300) to the time at which the average activity occurs for a decaying radionuclide, Tave . If image acquisition started at the Series Reference Time and the image has not been decay corrected, then Tave will be:

where: lambda = decay constant = (ln 2)/T1/2 T1/2 = Radionuclide Half Life (0018,1075) T = Actual Frame Duration (0018,1242)Note that Tave will be sooner than the midpoint of the Actual Frame Duration (0018,1242).

Example 3: For a short-lived radionuclide and a time-varying radiopharmaceutical distribution, an implementation with supplementary data (e.g. scanner count rates or blood sample data) sets the Frame Reference Time (0054,1300) to a derived time determined to be its best estimate of the time that the pixel values occurred.